It *should* work on all clone Genesis/Megadrive systems since it's as close to an original game cartridge as you can get.
"Gunstar Heroes[a] is a run-and-gun shooter video game, and the first game developed by Treasure and published by Sega. Treasure's debut game was originally released on the Sega Genesis in late 1993, and later on, ported to the Game Gear by M2. In February 2006, Gunstar Heroes was released as part of the Gunstar Heroes: Treasure Box Collection for the PlayStation 2. It is also available on the Wii's Virtual Console. In 2009, it was released on Xbox Live Arcade and PlayStation Network. In 2015, a 3D Classics version was released on the Nintendo 3DS eShop.
The game's premise was altered slightly for its western release, but is generally centered around the exploits of the Gunstars, a mercenary family out to stop the Empire, a dictatorship that seeks to revive an ancient weapon by using the power of four gems hidden throughout the planet. It has been listed among the best video games of all time by various publications." - Wikipedia
Brand new cartridge, manual, and box insert reproductions.